SENTIS™ Comprehensive Hereditary Cancer Test (Female)

SENTIS™ Comprehensive Hereditary Cancer Test (Female)
PurposeThe BGI SENTISTM Hereditary Cancer Panel analyzes germline mutations across 85 genes associated with 24 types of hereditary cancer, including some of the most common cancer types, such as hereditary breast, ovarian, colorectal, prostate, kidney, pancreatic, urothelial, pheochromocytoma, familial paraganglioma, melanoma, Esophageal, stomach and Endometrial Cancer etc. Identification of cancer-causing mutations can help guide treatment and health management decisions or guide further testing of at-risk relatives.Genes: ALK, APC, ATM, AXIN2, BAP1, BARD1, BLM, BMPR1A, BRCA1, BRCA2, BRIP1, CDC73, CDH1, CDK12, CDK4, CDKN1B, CDKN2A, CHEK2, EPCAM, EXT1, EXT2, FANCG, FH, FLCN, GALNT12, KIT, MAX, MEN1, MET, MLH1, MLH3, MRE11A, MSH2, MSH3, MSH6, MUTYH, NBN, NF1, NF2, NTHL1, NTRK1, PALB2, PDGFRA, PHOX2B, PMS1, PMS2, POLD1, POLE, PRSS1, PTCH1, PTCH2, PTEN, RAD50, RAD51C, RAD51D, RB1, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCA4, SPINK1, STK11, SUFU, TMEM127, TP53, TSC1, TSC2, VHL, WT1, XPC, GREM1, RHBDF2, ENG, MDH2, MC1R, MSR1, CFTR, FANCC, ACVRL1(ALK1), EPAS1, MITF.
Test CodeDX0645
Turnaround Time (TAT)20 Days
Sample TestedSentis Comprehensive Hereditary Cancer Panel (Female)
  • 5mL of peripheral blood OR 2mL of saliva OR ≥3µg good quality DNA
  • This test is designed to detect individuals with a germline pathogenic variant, and is not validated to detect mosaicism. It should not be ordered on tumor tissue
Methodology
  • HW2119
  • DNA Extraction and QC
  • Targeted Capture of 85 genes associated with 24 hereditary cancers
  • BGI Halos Health Analysis in One Step
  • Reports having information for targeted drugs (Precision Medicine)
  • Genetic Counselling
Advantages
  • All exons plus flanking intronic regions covered for all genes tested (85); one single assay that detects point mutations, deletions, insertions, duplications, rearrangements.
  • A streamlined sample-to-results workflow with MGI’s platform and automated on-premises NGS bioinformatics system, enabling effortless obtainment of insightful reports from samples.

PDF Title

Download