| Purpose | BGI VISTA™ EmbryoSeq PGT-A Test (Preimplantation Genetic Testing for Aneuploidy):- One in two human preimplantation-IVF embryos are chromosomally abnormal.
- Up to 40% of morphologically normal embryos harbor aneuploidies.
EmbryoSeq PGT-A Test evaluates embryos for extra or missing chromosomes. PGT is an option for any in vitro fertilization (IVF) patient.
PGT-A Test is used in conjunction with an IVF cycle. Embryos remain on-site at the patient’s IVF center. Cells are removed from an embryo and sent to LLC Biogen (BGI) Laboratory for genetic analysis.
PGT-A Test can improve the chance of a successful pregnancy while reducing the chance of miscarriage or chromosomal aneuploidies.Who needs to get tested?- Couples undergoing IVF.
- Patients at any age who have repeated implantation failure or recurrent pregnancy loss while undergoing IVF.
- Women over 35 years old undergoing IVF.
- Couples with recurrent miscarriages.
- Positive history of chromosomal abnormalities in the family.
- Diagnosed carriers of chromosomal aberrations.
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| Test Code | BGI VISTA™ EmbryoSeq PGT-A Test:
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| Turnaround Time (TAT) | 15 Days |
| Sample Tested | BGI VISTA™ EmbryoSeq PGT-A Test- Embryo Biopsy at D3 cleavage or D5 Blastocyst stage (5-7 days after fertilization).
- Cells sample taken from embryo and frozen.
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| Methodology | - Embryo Biopsy (Cells) at D3 cleavage or D5 Blastocyst.
- DNA Extraction and QC.
- Whole Genome Amplification.
- Library Construction & NGS.
- Data Analysis and Interpretation.
- •Embryo Report & Genetic Counselling.
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| Advantages | BGI VISTA™ EmbryoSeq PGT-A Test- SAFE; Need small no. of cells.
- High Accuracy; Sensitivity and Specificity Up to 99%.
- Comprehensive;
- Detect Aneuploidy and Deletions
- Duplications >4Mb of All 46 Chromosomes
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